Non-Invasive Screening Options
FIT + mt-sDNA (Cologuard) is emerging as the most commonly ordered non-invasive screening test. Its improved sensitivity for detecting colorectal cancer and advanced precancerous lesions—compared to FIT alone—makes it a popular option for many providers.
While other screening options listed below remain valuable in certain situations, they are used less often.
If you would like to explore the best screening option for you, talk to your healthcare provider or complete our contact form, and our team will follow up to support you.
Fecal Immunochemical Test (FIT)
FIT is a simple test that detects hidden blood in the stool, which may be a sign of colon cancer.
- Low cost: used primarily for population based screening programs.
- Annual testing required for effectiveness
- Not as sensitive as FIT + mt-sDNA (Cologuard) for colon cancer
- Does not accurately detect advanced precancerous polyps
- If positive, colonoscopy is required to complete the screening process
CT Colonography (Virtual Colonoscopy)
A CT scan of the colon that creates detailed images to detect abnormalities
- Highly sensitive for colon cancer
- Bowel prep is required
- If polyps or abnormalities are identified, a follow-up colonoscopy is necessary to complete screening. This is generally completed on a different day, requiring a second colonoscopy prep.
- Low dose radiation exposure
SHIELD Blood Test
SHIELD is a newly approved blood test that detects colorectal cancer by identifying tumor-specific markers in the bloodstream.
- Less sensitive than FIT + mt-sDNA at detecting colon cancer.
- Less sensitive than both FIT alone and FIT + mt-sDNA at detecting advanced precancerous lesions
- Improved specificity (less false positive tests) than FIT + mt-sDNA
